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The native carbomer was proven to be more potent than its fast swelling, freezedried modification. 1% bioavailabilty (Table I). In addition, the residence time of the drug in the blood was also significantly increased, as evident from the T values. The increased bioavailabilities are probably due to the mucoadhesive and enzyme inhibitory properties of carbomer (5). 9 0 Chitosan a "precious" waste material Chitosan is a natural-origin polymer obtained from chitin, waste material from the sea food industry, by alkaline or enzymatic deacetylation.

Sci. 1999, 7, 145-151. 12. Sieval, A. ; Thanou, M . ; Kotzé, A. ; Verhoef, J. ; Junginger, H. , Carbohydr. Polym. 1998,36, 157-165. 13. Kotzé, A. ; Thanou, M . M . ; Lueβen, H. ; De Boer, A. ; Verhoef, J. ; Junginger, H. , J. Pharm. Sci. 1999,88, 253-257. 14. Thanou, M . , Kotzé, A. , Lueβen, H. , De Boer, A. , Verhoef, J. , and Junginger, H. , J. Controlled Release 1999, In Press. 15. Kotzé, A. , Thanou, M . , Verhoef, J. , and Junginger, H. , Proceed. Intern. Control. Rel. Bioact. Mater 1998, 25, 479-480.

In this manuscript, we will briefly summarize the peptidyl substrates of peptide transporters and then mainly discuss the new structural features for peptide transporters focused on our new findings with amino acid ester prodrugs and other non-peptide substrates. PEPTIDYL SUBSTRATES O F PEPTIDE TRANSPORTERS In addition to the endogenous peptides, various therapeutic drugs are known as substrates of peptide transporters. As shown in Fig. 1, β-lactam antibiotics, angiotensin-converting enzyme inhibitors, renin inhibitors and bestatin are wellknown substrates for peptide transporters (2, 4, 21) and possess peptide-like chemical structures with a peptide bond, an α-amino group and a C-terminal carboxyl group.

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