By Jaroslav Sebestik, Milan Reinis, Jan Jezek
Dendrimers are again and again branched and approximately round huge molecules. they are often utilized in numerous clinical functions, comparable to anticancer polymeric nanomedicines and nanocarriers, gene companies and vectors in gene supply, distinction brokers for molecular imaging and vaccines opposed to infectious illnesses and melanoma. The hugely branched, multivalent nature and molecular structure of dendrimers cause them to perfect instruments for numerous tissue engineering purposes. This ebook describes diversified different types of dendrimers, their biomedical and physico-chemical functions in addition to convergent and divergent syntheses, click on chemistry and ligation concepts. it's a wealthy resource of knowledge for researchers in biochemistry and pharmacology engaged on drug improvement in addition to for natural chemists who're engaged in synthesis of dendrimers.
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Extra info for Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures
Synthesis of dendrimeric tumor-associated mucin-type glycopeptide antigens. Synthesis (7), 1113–1122 (2009) 13. : Multivalent interactions between lectins and supramolecular complexes: Galectin-1 and self-assembled pseudopolyrotaxanes. Chem. Biol. 14(10), 1140–1151 (2007) 14. : Preparation and in vitro evaluation of the antiviral activity of the acyclovir complex of a ˇ-cyclodextrin/poly(amidoamine) copolymer. J. Control Rel. 126(1), 17–25 (2008) 15. : Glycosylation regulates NK cell-mediated effector function through PI3K pathway.
Lipomic profiling in drug discovery, development and clinical trial evaluation. Curr. Opin. Drug Discover. Devel. 7(1), 112–117 (2004) 37. : Carbohydrates as the next frontier in pharmaceutical research. Chem. Eur. J. 11(11), 3194–3206 (2005) 38. : Guidelines for the next 10 years of proteomics. Proteomics 6(1), 4–8 (2006) 39. : Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells. Mol. Cell. Biochem. 359, 375–384 (2012) Chapter 4 Classes of Peptide-, Glyco-, and Glycopeptide Dendrimers It is a difficult task to create a simple, universal, clear, unambiguous, logical, and generally applicable classification or even nomenclature of different sorts of dendrimers.
Chem. Eur. J. 15(10), 2352–2361 (2009) Chapter 3 Sugar Code (Glycocode) The vast majority of signal transduction processes in most living organisms are caused by four sorts of biomolecules: nucleic acids, proteins, glycoconjugates, and lipids. The sequence and structure of nucleic acids as well as peptides and proteins have been extensively studied, including different sorts of interactions and functions (Fig. 1) [27, 31]. Genomics [16, 19, 25, 28], proteomics [15, 24, 29, 35, 38, 39], glycomics [4,8,12,17,22,26,27,31–34,37], and lipomics [7,9,18,21,36] represent four logically, chemically, and biologically interconnected areas of research approaches to living organisms.