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Natural polymers are readily available, inexpensive, and nontoxic. Raw silk, fibrinogen, and collagen have been incubated in SBF solutions to obtain mineralized biopolymers that can be used as biomimetic bone analogs (Takeuchi et al. 2003; Wei et al. 2008; Girija, Yokogawa, and Nagata 2002). However, since these polymers are protein-based, they may elicit undesired immunological responses when placed in vivo. Alternative natural materials are polysaccharide-based systems, several of which have been developed and used as biomineralization templates.

Part B, Applied Biomaterials, Vol. 67, No. 1, pp. 655–665. S. 2005, The Effect on Osteoblast Function of Colocalized RGD and PHSRN Epitopes on PEG Surfaces, Biomaterials, Vol. 26, pp. 5209–5220. , and Worch, H. 2005, Osteoconductive Modifications of Ti-Implants in a Goat Defect Model: Characterization of Bone Growth with SR µCT and Histology, Biomaterials, Vol. 26, No.  3009–3019. A. 2008, Controlled Drug Delivery in Tissue Engineering, Advanced Drug Delivery Reviews, Vol. 60, No. 2, pp. 229–242.

2005, Implant Surface Roughness Influences Osteoclast Proliferation and Differentiation, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol. 75, No. 2, pp. 251–256. J. 1989, Bone Cell Physiology, Endocrinology and Metabolism Clinics of North America, Vol. 18, No. 4, pp. 833–858. , and Samitier, J. 2009, Effects of Artificial Micro- and NanoStructured Surfaces on Cell Behaviour, Annals of Anatomy—Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft, Vol.

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