By Niklaus Wirth

One of many vintage texts on information buildings and algorithms! Examples are in Pascal.

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E: In this invasive adenocarcinoma, there is fibrosis at the center of a tumor that exhibits extension of tumor cells. F: High magnification of this tumor (E) reveals a sclerotic response to tumor cells with pink fibers aligned parallel to the elongated fibroblastic nuclei. 12 Cytology of adenocarcinoma showing Papanicolaoustained cluster of adenocarcinoma cells. These are large cells with high N/C ratio and prominent nucleoli (dark circular structure in nucleus [Nucl]). Under the microscope, the cell cluster has a three-dimensional structure and a mucus vacuole (Muc) is present at one margin of the cluster.

C: Bland cells with speckled chromatin (touch prep, H&E, 60ϫ). D: Carcinoid with hyalinized stroma (cell block, H&E, 40ϫ). E,F: Spindle cell carcinoid (Diff-Quik and Papanicolaou stains, 100ϫ). 6 Atypical carcinoid. A: Epithelial cells with mild pleomorphism (Diff-Quik, 60ϫ). B: Loose cell clusters with speckled chromatin and rare mitotic figure (touch prep, H&E, 60ϫ). 7 Small cell carcinoma. A: Clusters and single cells with scant cytoplasm and focal nuclear molding (Diff-Quik, 40ϫ). B: Small cell carcinoma with rosettes, nuclear molding, and crush/smearing artifact (DiffQuik, 40ϫ).

5 PET/CT in a patient with squamous cell carcinoma of the left upper lobe. FDG uptake is present in the primary tumor and an adjacent hilar LN (A,B). PET also shows a focal hot spot suspected for N2 disease in level 2L (A,C arrow ). PET/CT fusion images project the hot spot in brown fat tissue (D,E). At thoracotomy with LN, dissection confirmed the absence of mediastinal involvement (pT2N1). 7 Right upper lobe large cell carcinoma (A) with right hilar and paratracheal adenopathy (B), both clearly FDG avid on PET/CT fusion images.

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