By Suzuki H.

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Hormonal dysregulation may result from pathologic conditions present in critically ill children, such as the systemic inflammatory response syndrome. Independent of these hormones, Na+–K+–ATPase activity, and hence intracellular K+ concentration, is also affected directly by plasma K+ and cytosolic ATP concentrations [37, 41, 42, 78]. Lastly, certain pathologic states may promote rapid K+ release from cells, faster than that which Na+–K+–ATPase can rectify, usually resulting from cell lysis. Examples include tumor lysis, rhabdomyolysis, and hemolysis [40, 67].

Hansen JE, Simmons DH (1977) A systematic error in the determination of blood pCO2. Am Rev Respir Dis 115(6):1061–3 34. Harsten A, Berg B, Inerot S, et al. (1988) Importance of correct handling of samples for the results of blood gas analysis. Acta Anaesthesiol Scand 32(5):365–8 35. Hill JB (1973) Salicylate intoxication. N Engl J Med 288(21):1110–13 36. Hindman BJ (1990) Sodium bicarbonate in the treatment of subtypes of acute lactic acidosis: physiologic considerations. Anesthesiology 72(6):1064–76 37.

3 Causes of Hyperkalemia . . . . . . . . . . . 4 Diagnostic Approach to Hyperkalemia . . . . . 5 Therapy of Hyperkalemia . . . . . . . . . . . 5 Other Issues . . . . . . . . . . . . . . . . 1 Point-of-Care Testing . . . . . . . . . . . . 2 Morbidity/Mortality from Hyperkalemia: Prescribing K+ Salts in the PICU . . . . . . . . 50 References . . . . . . . . . . . . . . . . . . . . G. Kiessling et al.

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